How Many Units Is 0.25 mg of Semaglutide? (Every Vial Strength)

On a U-100 insulin syringe, 0.25 mg of semaglutide is 25 units at 1 mg/mL, 12.5 units at 2 mg/mL, 10 units at 2.5 mg/mL, 6.3 units at 4 mg/mL, 5 units at 5 mg/mL, 2.5 units at 10 mg/mL.

At 2.5 mg/mL, the strength most often seen on compounded labels, it is 0.1 mL, which is 10 units. Use the calculator with the strength printed on your own vial.

0.25 mg of semaglutide in units at every strength

0.25 mg of semaglutide at every vial strength, on a U-100 insulin syringe. Listed doses are for conversion only. Your prescriber sets your dose.
Vial strength	Volume	Units (U-100)
1 mg/mL	0.25 mL	25 units
2 mg/mL	0.125 mL	12.5 units
2.5 mg/mL	0.1 mL	10 units
4 mg/mL	0.063 mL	6.3 units
5 mg/mL	0.05 mL	5 units
10 mg/mL	0.025 mL	2.5 units

Dose ↔ units

Vial type Liquid vial (strength on label) Powder vial (I add water)

Strength (mg/mL)

I know my… Dose in mg Units

Dose (mg)

Syringe

How long will my vial last?

Uses the vial and dose from the calculator above.

Real vials can hold slightly more or less than the label says, and a little is lost in the needle.

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Same dose, different units

At 2.5 mg/mL, 0.25 mg is 10 units. Drawing those same 10 units from a 5 mg/mL vial gives 0.5 mg, not 0.25 mg. Always check the mg/mL on the vial you are using.

In July 2024 the FDA warned about dosing errors with compounded semaglutide, including mix-ups between mg, mL and units (FDA alert). The same math applies to any vial.

Questions

How many mL is 0.25 mg of semaglutide?

It depends on the vial: 0.25 mL at 1 mg/mL, 0.125 mL at 2 mg/mL, 0.1 mL at 2.5 mg/mL, 0.063 mL at 4 mg/mL, 0.05 mL at 5 mg/mL, 0.025 mL at 10 mg/mL.

Is 0.25 mg of semaglutide the same number of units on every vial?

No. The units depend on the strength printed on the vial: 25 units at 1 mg/mL, 12.5 units at 2 mg/mL, 10 units at 2.5 mg/mL, 6.3 units at 4 mg/mL, 5 units at 5 mg/mL, 2.5 units at 10 mg/mL.

More charts

mg vs mL vs units explained